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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Marchesini G., Bugianesi E., Burra P., Marra F., Miele L., Alisi A., Vajro P., Masarone M., Petta S., Persico M., et al

The researchers found that GLP-1 receptor agonist initiation was associated with a reduced risk for disorders related to alcohol use, cannabis use, cocaine use, nicotine use, opioid use, and other SUDs compared with initiation of SGLT-2 inhibitors (hazard ratios, 0.82, 0.86, 0.80, 0.80, 0.75, and 0.87, respectively) and with a reduced risk for the composite outcome of all incident SUDs (hazard ratio, 0.86)

For comparison, most peptides have half-lives measured in hours, and even semaglutide (a long-acting GLP-1) is about 7 days

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8 Key takeaways for Australian analysts If you only remember five things, make them these: GLP-1 is not one market

Due to its significant weight loss effects, tirzepatide has also shown potential in managing conditions like non-alcoholic fatty liver disease (NAFLD), though further research is necessary (43)(46)