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Notably, whereas Gcg is robustly expressed in -cells, its expression is suppressed in -cells through binding of pancreatic and duodenal homeobox 1 (Pdx1), Pax4, and homeobox protein Nkx6.1 to the G1 element, thereby competitively preventing the binding of Pax6/Maf heterodimers to the G1 element (Figure 2) [100,139,140]

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found no adverse fetal effects (29)

Abstract Importance: Glucagon-like peptide-1 (GLP-1) receptor agonists were first approved for the treatment of type 2 diabetes in 2005

Exenatide (Byetta) was the first GLP-1R agonist to be prescribed for the treatment of T2DM and is a synthetic analog of the GLP-1R agonist, Ex-4

Overington, J