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[82] found in rat experiments that semaglutide protected against exercise-induced myocardial injury by activating the AMPK pathway, increasing autophagy, and reducing the production of reactive oxygen species (ROS) and inflammation-related proteins

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For patients also taking insulin or sulfonylureas, it's important to check blood glucose levels when feeling cold, as hypoglycemia can present with cold, clammy sensations

The difference was that people in the control group started taking a different Type 2 diabetes drug called a DPP-4 inhibitor after their cancer diagnosis