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It is also essential to clarify for sites that central reviewers must read participant MRI data before randomization
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Frankfurt / Main: Edition Chimaira
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
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This creates a self-reinforcing cycle: low testosterone promotes further fat accumulation, which drives more aromatase conversion, leading to even lower testosterone (Cohen, 1999, Journal of Clinical Endocrinology & Metabolism )
