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Important safety considerations include a boxed warning for thyroid C-cell tumors, contraindications in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and risks of pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or insulin secretagogues), and acute kidney injury

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Methods: A comprehensive search of MEDLINE, Embase, and Cochrane databases was conducted through February 27, 2025

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GLP-1 receptor localization in monkey and human tissue

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