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[11] In a randomized controlled trial (RCT) comparing liraglutide, glargine, glimepiride, and sitagliptin (all added to metformin) with a follow-up of five years, glargine and liraglutide were modestly more effective in achieving and maintaining target HbA1c, [20] with no difference in outcomes of microvascular and cardiovascular disease

Additionally, clinicians must consider comorbid conditions, concomitant medications, renal function, and patient preferences when integrating GLP-1RAs into treatment plans

doi: 10.1056/NEJMoa2032183 22 PratleyREArodaVRLingvayILudemannJAndreassenCNavarriaAet al

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