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Conclusion Clinical trial data from large, controlled studies demonstrate the efficacy and safety of GLP-1 agonists in terms of A1C reduction, beneficial effects on body weight, and a low risk for hypoglycemic events when used as monotherapy

The ING healthcare analyst Diederik Stadig has calculated that the overall cost of obesity to the UK is 100bn a year, with 19bn borne by the NHS

Under physiological conditions, postprandial GIP levels are approximately 3 4 times higher in molar concentration compared to GLP-1, irrespective of diabetic status (39)

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Real-world benefits : The perceptions of different AOMs and their value propositions are firming up in 2025, as more doctors gain hands-on experience with AOMs and we are beginning to see real-world outcomes: Doctors awareness and perceptions of AOMs are still developing and vary considerably between prescriber specialties

Providers may suggest alternatives to medications like semaglutide, such as dietary changes, lifestyle coaching, or different diabetes medications if needed