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Increased cholesterol release into bile can disrupt balance and promote gallstone formation

On the basis of these findings, the overall efficacy and safety of tirzepatide has been investigated in the SURPASS clinical trial programme in comparison with placebo and other glucose-lowering medications including GLP-1 RAs and basal insulin [11]

This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal

Thus, creating a void to conduct future studies to examine longer duration treatment to check their prolonged effects (98)

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doi: 10.1186/s13075-018-1660-6