is metformin a glp 1 receptor agonist Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research Glucagon-like peptide-1 receptor: mechanisms and
Description
The researchers were focused on diabetes (not obesity) treatment, and I have not included their calculations of the cost of gaining approval for biosimilars

Dehydration increases heart rate because the heart must beat faster to maintain blood pressure with reduced blood volume

Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, Knig D

[DOI] [PMC free article] [PubMed] [Google Scholar] 15
Native GLP-1 was simply too evanescent
In terms of ORCs, it is plausible that some may be relevant to an out-of-pocket market even if not deemed payer relevant
