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These are not necessarily drawbacks - they reflect the company's current business model and scope

Michalski et al., 2020

These patients should not be reassured as low risk, but rather monitored closely and managed proactively

2014;10(1S):S337

10.1016/j.phrs.2015.03.010 310

For researchers starting a comparative protocol, the practical implication is that tirzepatide offers a broader reference base for benchmarking assay performance and expected magnitudes of effect, while retatrutide provides a more mechanistically novel reference for triple-agonist work