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HUVECs (Human umbilical vein endothelial cells) were purchased from American Tissue Culture Consortium (ATCC) and cultured in RIPM 1640 medium supplemented with 10% FBS (Gibco, Invitrogen, NY, USA) and 1% penicillin-streptomycin

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Designed for type 2 diabetes management, it helps to regulate blood sugar levels

This additional mechanism also introduces the dysesthesia side effect not seen with tirzepatide

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While the systemic biological effects of semaglutide that indirectly benefit MASLD/MASH are robustly validated, a knowledge gap persists concerning the drug's direct effects on the liver, alongside the scientific controversy surrounding the gene and protein expression of GLP1 receptor (GLP1R) in the liver [12]