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Regulatory agencies increasingly recognize the value of surrogate endpoints, adaptive trial designs, and biomarker-driven patient stratification, particularly in areas of high unmet need

Thus, while thyroid safety remains under surveillance, the broader evidence suggests that the benefits of GLP-1RAs extend beyond glucose lowering to encompass immunometabolic effects that could plausibly influence AITD (Figure 1)
Sills, E

Kocinsky HS, Dynia DW, Wang T, Aronson PS
Available from: 23 JalalMJA

[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Johansen OE, Whitfield R
