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Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: A 1-year, randomized, double-blind, placebo-controlled study

Missing doses or varying the time by several hours each day creates peaks and valleys in blood concentration that reduce overall effectiveness and can worsen side effects like nausea

Careful planning reduces unnecessary variables and helps protect valuable research time and resources
Together, these mechanisms lead to a more balanced metabolic response

Consensus of Chinese experts on oral hypoglycemic drugs combined with initial insulin in the treatment of type 2 diabetes mellitus

Mechanisms of NAFLD development and therapeutic strategies
