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Abstract Purpose of Review The glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) liraglutide and semaglutide, and the dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RA tirzepatide are approved for the treatment of overweight and obesity

We found that the GLP-1 agonist group was superior to the usual care group in all outcomes and all subgroups except in BMI outcome in the 3 months subgroup

An obvious increase in risk of aortic inflammation and atherosclerosis was seen in GIP- knocked out mice, despite maintained glucose homeostasis and reduced weight gain

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This is likely to result in increased side effects such as nausea and vomiting

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