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Transforming Body Composition With Semaglutide in Adults With Obesity and Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne) 15: 1386542

Effects on weight SGLT2-I on average result in a small reduction in weight, possibly due to reduction in glucose reabsorption

Dehydration and micronutrient deficiencies common on GLP-1 therapy further compromise disc hydration and bone density

In Asia, there are ~10M people employed in fabric mills meaning a 20% decline in fabric demand could cause 20%+ job losses. Jeffries Report

Tirzepatide activates both GLP-1 and GIP receptors, creating dual appetite suppression

The strength of early appetite control varies between individuals based on genetics, baseline metabolic health, and starting dose