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Phentermine originally came to market in 1959 and is currently the longest-standing weight-management medication in the world

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Abdulreda MH, Rodriguez-Diaz R, Caicedo A, Berggren PO

[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

The Physiology of Glucagon-Like Peptide 1

However, he joked last year about losing his A-se because of it