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Semaglutide can be used long-term under the supervision of a healthcare professional

GLP-1 therapy is ideal for adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related health condition, who have struggled with other weight loss methods

Tesofensine works on brain neurotransmitter pathways and the GLP-1 drugs work on gut hormone pathways, so they are mechanistically different