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Main body The influence of DPP-4 on bone metabolism occurs through two axes

In laboratory research, it is utilized to study the potentiation of metabolic signaling and the regulation of nutrient-stimulated hormone secretion

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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1
