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The culture medium on both the donor and the acceptor compartment was changed every second day

Topiramate, a carbonic anhydrase inhibitor, promotes a decrease in urinary citrate excretion, increase in urinary pH, and hypercalciuria, leading to an increased risk of stone formation

Additional findings published in January 2025, along with actions taken by the Danish Medicines Agency, prompted further scrutiny of the drugs vision-related side effects

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