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Trial registration NCT02723110, NCT02465515 and NCT01144338.

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On December 14, 2023, "Science" magazine announced the top ten scientific breakthroughs of the year

Why protein intake drops on GLP-1 When appetite is lower, large high-protein meals can feel difficult to finish

Method We systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes