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N Engl J Med 2012;367:2204-13.ArticlePubMed 14

Phasic burst firing of midbrain dopamine neurons and subsequent phasic release of dopamine in the nucleus accumbens are key neurophysiological mechanisms that implicate mesolimbic dopamine signaling as critical for goal-directed behaviors including drug reinforcement [3641]

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A human trial analyzing patients on Semaglutide injections that shows patients who stopped at lower doses of GLP-1 medications experienced less side effects

Healthcare professionals can assess whether dose adjustment, temporary treatment interruption, or switching to an alternative GLP-1 agonist might be appropriate