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If orforglipron receives approval for obesity in April 2026, it will enter a market that Morgan Stanley estimates could reach $100 billion annually by the early 2030s, potentially transforming Eli Lilly's already dominant position in the metabolic disease space

Men more commonly report erectile dysfunction and reduced desire

Calocurb is a daily, prescription-free GLP-1 activator capsule, much like the popular injections that have taken over conversations about weight loss

In EVOKE and EVOKE+, oral semaglutide lowered several cerebrospinal-fluid markers of Alzheimers pathology, including phosphorylated tau and total tau, by up to roughly 10%, yet produced no measurable slowing of clinical decline

Patients with diabetes on one of several GLP-1 receptor agonists were less likely to be diagnosed with depression and anxiety compared with those not on those medications, researchers found

These medications appear to reduce craving and compulsive reward-seeking in at least some people, and the evidence for a broader role in addiction treatment is strong enough to justify careful clinical interest