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When tirzepatide activates both GIP and GLP-1 receptors, something remarkable happens: The GLP-1 component handles the usual suspects: reducing appetite, slowing down how quickly your stomach empties, and boosting insulin secretion when blood sugar rises

Both tirzepatide and retatrutide have undergone rigorous clinical trials, and the weight loss data from these studies provides the most reliable comparison available

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Lourival Monaco, GLP1 Adoption and Its Impact on Food Demand , Purdue Univ

doi: 10.1038/nrm3013 51

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