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Description
New England Journal of Medicine , 393 (18), 1796-1806

Published research on Akkermansia muciniphila has identified a specific protein (P9) associated with GLP-1 secretion in preclinical models
The Lancet 402 , 613626 (2023)
injection of 100 nmol kg 1 MK-801 ( n = 8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 , GLP-1MK-801 ( n = 8 mice), or vehicle (isotonic saline, n = 8 mice) in DIO mice

Importantly, in these and other clinical trials, the safety profile of GLP-1 receptor agonists was well established

In February 2026, about a year after the most recent GLP-1 shortage ended, the FDA issued a notice vowing to take action against mass-marketed compounded GLP-1s, including legal action and the seizure and injunction of non FDA-approved drugs
