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Shen HR, Xu X, Li XL

Meier JJ, Gallwitz B, Salmen S, Goetze O, Holst JJ, Schmidt WE, et al

Cellular senescence: A key therapeutic target in aging and diseases

The investigators are assessing a three-point major adverse cardiovascular event endpoint (myocardial infarction, stroke, and cardiovascular death), over an estimated maximum of 54months (NCT04255433, estimated study completion in October 2024)

Analysis of cohorts Our meta-analysis included four studies

The PK studies with lixisenatide [36], liraglutide [24] and semaglutide [16, 27] demonstrated reduced C max and delayed t max of atorvastatin, but overall minor changes in the AUC were not considered to be of clinical importance (Table 3)