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The relationship between thyroid function, body weight, and GLP-1 physiology is complex
doi: 10.1056/NEJMoa2302392 75 GloyVLBrielMBhattDLKashyapSRSchauerPRMingroneGet al
In laboratory settings, the Glucagon component has been noted to elevate heart rate in subjects more significantly than standard GLP-1 agonists.
Thompson CA, Sturmer T
Preclinical studies in obese and diabetic rodent models suggest that GLP-1 receptor agonists enhance spermatogenesis, hormone profiles, and sperm function through two intracellular signaling pathways: cyclic adenosine monophosphate and protein kinase A (cAMP/PKA), and phosphoinositide 3-kinase and protein kinase B (PI3K/Akt)
PMCID: PMC5993535
