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Impact of gastrointestinal adverse events on weight loss (STEP 13) Among participants on treatment at week 68 with a body weight assessment, the observed placebocorrected weight loss from baseline to week 68 for semaglutide 2.4 mg was 14.4 percentage points in the STEP 1 trial, 7.6 percentage points in the STEP 2 trial and 12.7 percentage points in the STEP 3 trial

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When food sits in the stomach and proximal small bowel longer than normal, anaerobic bacteria gain extra time to break down sulfur-containing amino acids (methionine, cysteine) into hydrogen sulfide (HS) gas