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Overview of efficacy, side effects, and key challenges GLP-1 receptor agonists such as semaglutide and liraglutide, as well as combination agents like tirzepatide (which adds glucose-dependent insulinotropic polypeptide receptor agonism)all hereafter referred to as GLP-1s for brevityare effective new agents for obesity treatment which demonstrate weight reduction, weight maintenance, and reduced morbidity and mortality

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These older GLP-1 drugs remain in use but have been largely overtaken by semaglutide and tirzepatide in new prescriptions

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