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[1] [2] Each site offers adequate subcutaneous tissue for safe injection

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Microdosing means taking a smaller amount of medication more frequentlyusually twice a week rather than once

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Every-three-month infusions were continued through month 36 of the HOPE-2-OLE study

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis