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The effect of the Thr 11 Ala substitution was, however, smaller (13-fold decrease) compared with Phe 12 Ala and Thr 13 Ala substitutions (133-fold decrease), whereas GLP-1 potency was only significantly affected by the latter two substitutions

10.1089/dia.2011.0050

Skin flap necrosis and poor wound healing may also occur, especially in patients with compromised vascularity or ongoing weight fluctuations, he noted

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