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Introduction/Objectives Glucagon-like peptide-1 (GLP-1)based therapies have emerged as a major advance in cardiometabolic care

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Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

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In addition to outcomes data, payers will be guided by cost-effectiveness considerations, e.g., as assessed by European HTA bodies or ICER, with implications for drug prices to meet acceptable cost-effectiveness thresholds