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Semaglutide itself is a potent weight loss agent, but Tirzepatides dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonism might afford it an edge in effectiveness

References: Rodriguez KM, Pastuszak AW, Lipshultz LI

GLP-1R positive nerve fibres (Abcam antibody, left panels) and PGP9.5 (right panels) in mucosal sigmoid colon biopsy specimens, from topcontrol, middle and bottomIBD, magnification x40

European Journal of Gastroenterology & Hepatology

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Cardiovascular and renal outcomes of dual combination therapies with glucagon-like peptide-1 receptor agonists and sodium-glucose transport protein 2 inhibitors: a systematic review and meta-analysis