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This excess risk stems from multiple factors including accelerated atherosclerosis, increased inflammatory state, abnormal blood clotting tendencies, and the metabolic damage caused by chronic hyperglycemia

Semaglutide While past research has shown tirzepatide produces greater weight loss than semaglutide in patients with type 2 diabetes, data from head-to-head trials comparing these medications in patients without diabetes are not yet available

As of May 2026, compounded semaglutide and tirzepatide are available through patient-specific prescription models at telehealth platforms including Sunlight

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Study: Most Patients Can Safely Continue Weight Loss, Diabetes Drugs Before Gynecologic Surgery First gynecologic-focused review supports newer guidance on continued use of GLP-1 medications Most patients taking popular weight loss and diabetes medications such as Ozempic and Wegovy can safely continue them before gynecologic surgery, according to a new journal article from ChristianaCare published in Obstetrics & Gynecology