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But glucagon receptors are also expressed in cardiac tissue, where their activation has two well-documented effects: A positive chronotropic effect increasing heart rate and a positive inotropic effect increasing the force of heart contractions

[5] Recognition of potential semaglutide overdose relies primarily on identifying an exaggerated pharmacological response rather than unique toxicological symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Lincoff A.M., Brown-Frandsen K., Colhoun H.M., et al

IL-1 is known to disrupt long-term potentiation and synaptic transmission [34] while TNF- alters postsynaptic AMPA receptor regulation [35], thereby impairing synaptic homeostasis

And individuals using GLP-1 for reasons beyond weight loss, such as metabolic health optimization or inflammatory conditions, may not need full therapeutic doses