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However, evidence from human cell-based experiments suggests that these benefits are unlikely to result from direct actions on hepatocytes or HSCs, instead reflecting indirect metabolic and anti-inflammatory mechanisms

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Practice Intermittent Fasting (If Appropriate) Many individuals using GLP-1 find intermittent fasting easier

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According to the MHRA/EMC SmPC, these include: Vomiting reported in approximately 8% of patients Abdominal pain and discomfort cramping or bloating may make it difficult to find a comfortable sleeping position Acid reflux or heartburn which can worsen when lying down Hypoglycaemia (low blood glucose) may occur, particularly when Ozempic is used in combination with sulphonylureas or insulin

These observations lend support to the hypothesis that GLP-1/GLP-1R axis might directly act on ovarian MGCs to promote the follicular development in a dose-dependent manner, likely contributing to the oocyte maturation in PCOS