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The chronotropic effect of GLP-1 is independent of beta- and/or alpha-adrenergic blockades To test if the sympathetic nervous system is involved in the GLP-1-induced heart rate increase, we repeated the GLP-1 infusion experiments in the presence of relevant doses of pharmacological blockers of the beta- or alpha-adrenergic receptors after a first (control) GLP-1 dose ( Figure 2 )

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and 0.35 (95% CI, 0.33-0.36) for tirzepatide

These are synthetic versions of the hormone, engineered to be resistant to breakdown by the DPP-4 enzyme

Individuals should be counseled to avoid refined carbohydrates (i.e., refined grains, flour, starches, sugars), sugar-sweetened beverages, red and processed meats, and most fast foods, ultraprocessed sweets, and savory snacks (Table 6)

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