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Fatigue that persists beyond 46 weeks, worsens despite supplementation, or significantly limits daily function warrants a provider conversation about dose reduction, temporary pause, or alternative therapy

This impact might potentially ameliorate aspects of metabolic hypogonadism

Many patients find that adding strength training or resistance exercise during this phase helps preserve metabolism and reduces appetite rebound
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Anal Biochem 72:248254

The combination of glaucoma and diabetic retinopathy could make it harder to control both conditions
