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Weight loss of at least 5% was observed in 63.2 and 27.1% of the patients, respectively, and weight loss 10% was seen in 33.1 and 10.6% of the patients, respectively

This effect is more clear in animal studies, where weight-matched controls are easy to achieve by restricting access to food and any changes in diet are controlled for

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However, in chloralose-anaesthetised pigs, electrical stimulation of the vagal trunks at the level of the diaphragm had no effect on GLP-1 secretion, and human cephalic phase studies and studies in vagotomised humans found similar results 2830

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The companies that can orchestrate these moving parts through strong project management leadership, not just add reactors or fill-finish lines, will define the next wave of global CDMO leadership