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GLP-1 patients often notice looseness in the arms, sagging in the abdomen and laxity in the thighs

A possible side effect of taking insulin is low blood glucose (hypoglycemia)

This occurs because GLP-1 receptor activation reduces the coordinated muscular contractions (peristalsis) that normally propel stomach contents into the small intestine

As reported by the American Journal of Managed Care, the approval of an oral semaglutide formulation marked the beginning of what many are calling the oral GLP-1 era. In December 2025, the FDA approved the Wegovy (semaglutide) tablet as the first once-daily oral GLP-1 receptor agonist indicated for chronic weight management in adults with obesity or overweight

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A really important overlooked fact of GLP-1 agonists is that 40% of weight loss is unfortunately muscle mass, indeed a major side effect of GLP-1 agonists