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These effects are typically most pronounced during treatment initiation and dose escalation, often improving over several weeks

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Fonseca VA, Capehorn MS, Garg SK, Jodar Gimeno E, Hansen OH, Holst AG, Nayak G, Seufert J

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For evaluating drug products or categories of drug products for inclusion on the DDC list, FDA proposed to establish the following criteria: formulation complexity, drug delivery mechanism complexity, dosage form complexity, complexity of achieving or assessing bioavailability, compounding process complexity, and complexity of physicochemical or analytical testing of the drug product or category of drug products

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Others may find that the allodynia returns at the same dose threshold

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