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Semaglutide has 94% sequence homology with native GLP-1 and three key structural differences that provide extended pharmacokinetics [16] (Fig
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29,54 The STEP-HFpEF trial reported a reduction in systolic BP by an average of 4.9 mmHg in the semaglutide group, compared to a reduction of 2.0 mmHg in the placebo group, in a mean difference of 2.9 mmHg
