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Patients taking semaglutide should expect some common side effects, including nausea, vomiting, diarrhea, and constipation

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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11

[DOI] [PubMed] [Google Scholar] 28.Glucagon-like peptide-1 receptor: mechanisms and advances in therapy

32 In 2026, many Chinese firms are using salt-form patents and polymorph-specific claims to survive invalidation challenges at the CNIPA and USPTO