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doi: 10.1038/s41591-025-03774-9, 95 MathesC

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The average proportion of GLP-1 claims that were rejected rose from 30% before Wegovys launch, to 41% after Mounjaro hit the market, reflecting a change in the underlying access profile of GLP-1s for patients

Interestingly, certain classical inflammatory stimuliincluding lipopolysaccharide (LPS) and pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) can, in turn, induce GLP-1 secretion