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Methods Post-hoc mediation analyses were conducted to evaluate weight-loss dependent and weight-loss independent effects of tirzepatide on SBP reductions across the 5 SURPASS studies

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The World Health Organisation's 2026 global guidelines on GLP-1 therapies for obesity explicitly recommend combining medication with intensive behavioural interventions, including structured goal-setting for diet and physical activity

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DO NOT USE FOR WEIGHT REDUCTION

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Dermatologist Amanda Oakley reviews their diagnosis and treatment

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