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Semaglutide, marketed as Ozempic (for diabetes) and Wegovy (for weight management), is a GLP-1 receptor agonist that has been approved by the FDA for both type 2 diabetes and chronic weight management

But as insulin sensitivity improves and metabolic function normalizes, many people describe feeling more energetic overall

Research published in Nature in April 2026 identified a variant in the GLP1R gene associated with reduced efficacy across GLP-1 medications

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Tirzepatide carries an FDA boxed warning for thyroid C-cell tumors and is contraindicated with a personal or family history of medullary thyroid carcinoma or MEN2