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Description
Both drugs have gone through full Phase 3 trials and the complete regulatory review process

The workaround: if you have a contraindication to step therapy medications (for example, cardiovascular disease that contraindicates phentermine, or chronic diarrhea that contraindicates orlistat), your provider can request a step therapy override

Dischinger U, Ktzner L, Kovatcheva-Datchary P, Kleinschmidt H, Haas C, Perez J, et al
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What is the Precision Peptide Genetic Test, and how does it help me choose a medication

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There is a risk of contamination and overdosing due to the lack of standardization
