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All glucagon-like peptide-1 receptor agonists (GLP-1 RAs) licensed for type 2 diabetes mellitus (T2DM) are facing a national shortage, the government has said

Physicians may prescribe compounded medications as needed to meet patient requirements

The inclusion of GLP-1s in the negotiations reinforces the trend of heightened regulatory scrutiny, reduced pricing flexibility, and potentially growing pressures on long-term margins

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The review further distinguishes between established outcome benefits (CVD, CKD, and OSA) and conditions still under investigation (neurodegeneration, arthritis, and some liver endpoints)

Side effects, contraindications, and monitoring protocols remain unchanged