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The 3 elective surgery studies had a combined risk ratio of 1.00 [0.76, 1.30]
42) In SUSTAIN-6, patients treated with semaglutide had a lower risk of developing or worsening nephropathy, but a higher risk of complications from diabetic retinopathy than those receiving placebo (40)
And weight gain is often driven by multiple factors: hormones, insulin resistance, medications, sleep deprivation, stress, and muscle loss
Obesity is characterized by hyperinsulinemia, increased leptin resistance, systemic inflammation, and altered sex steroid metabolism
