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In clinical trials, retatrutide achieved 24.2% weight loss at 48 weeks versus tirzepatide approximately 21% at 72 weeks, suggesting stronger overall appetite and metabolic effects

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Therefore, postmarketing surveillance and real-world evidence play a crucial role in continuously monitoring the safety and effectiveness of medications once they are in widespread use [Reference Zhou, Peng, Lin, Jiang, Peng and Gu29Reference Fan, Hu, Yang and Zhao31]

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Individual results will vary based on dosage, treatment plan, and individual response

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