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doi: 10.1056/NEJMc2106918

Drawbacks: Higher doses from LillyDirect are $449 per month (and this is for vials and needles, not easy-to-use pens)

So, Tirzepatide dose-dependently reduced voluntary alcohol consumption, prevented binge and relapse-like drinking, Studies have shown reduced alcohol use in patients prescribed GLP-1 agonists

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However, an exposure-response modeling analysis suggested that an initial deterioration in A1C may be seen when switching from dulaglutide 1.5 mg once weekly or liraglutide 1.2/1.8 mg once daily to the initial recommended 0.25 mg once-weekly dose of subcutaneous semaglutide (62)